polygonum multiflorum liver damage

To determine the main clinical and pathological characteristics of liver toxicity induced by PMT and the clinical course after its cessation. This would be a hand full of our capsules per day. In case series, the causes of consuming HSW products include grey hair, hair loss, hypertension, coronary heart disease, hyperlipidemia, osteoarthritis, insomnia, dizziness, and health care; the top diseases were gray hair and hair loss [17–21]. : a review. Polygonum Multiflorum for Liver Health.  |  Liver damage associated with HSW is reversible, and, after active treatment, the majority can be cured. (Fam. People should be alert to liver damage when taking HSW preparations. To summarize the characteristics and analysis of relevant factors and to give references for prevention and further study of liver damage associated with Polygonum multiflorum Thunb. See this image and copyright information in PMC. 2008;26(8):1687–1689. Of the 450 patients, two cases who received liver transplantation and seven who died, the remaining 441 cases recovered or had liver function improvement after discontinuing HSW products and conservative care. In case reports, the length of 64 patients’ hospitalization ranged from 6 to 120 d, with a median of 29.5 (Table 6). As a Chinese herb, it was recorded most early in “Kaibao Bencao” published by the imperial court of the Song Dynasty (973-974 A.D.) [1]. There isn't enough information available to know if … Results. Polygonum multiflorum (PM) is a well‐known Chinese herbal medicine that has been reported to induce inflammation‐associated idiosyncratic liver injury. (PM) have been reported since 2006, which aroused widespread concern. Xiang Lei, Jing Chen, Jingtian Ren, Yan Li, Jingbo Zhai, Wei Mu, Li Zhang, Wenke Zheng, Guihua Tian, Hongcai Shang, "Liver Damage Associated with Polygonum multiflorum Thunb. (PM) induced DILI (PM-DILI)have received much attention This study aimed to identify a simple and high-efficiency approach to PM-DILI diagnosis via metabolomics analysis. : a systematic review of case reports and case series. The full texts of potentially relevant articles were retrieved for detailed assessment. According to case reports and case series, most of the patients had been hospitalized with jaundice, fatigue, anorexia, and yellow or tawny urine. 2019 Sep 25;2019:5482896. doi: 10.1155/2019/5482896. Xiang Lei and Jing Chen contributed equally to this work. Frontiers of Medicine 9(4): 457-467. 2015 Jan 15;159:158-83. doi: 10.1016/j.jep.2014.11.009. HHS (HSW), we provide a systematic review of case reports and case series about liver damage associated with HSW. While there are many HSW-containing products, the most well-known product is like Shou-Wu-Pian, which is usually consumed as an antiaging product, or as a tonic for dizziness with tinnitus, and also appears to be efficacious in the treatment of premature greying of hair, lumbago, spermatorrhea, leucorrhea, and constipation. P. multiflorum and its extracts should be considered hepatotoxic; however, the plant is widely used in traditional Chinese medicine and Ayurvedic medicine for its rejuvenating and toning properties, to increase liver and kidney function, for treatment of cognitive di… Methods. High cholesterol 4. Warning If you have liver disease, or if liver disease runs in your family, do not take Fo-Ti. Most of them recovered quickly after they stopped taking the herb. The effective mechanism of 2, 3, 5, 4′-tetrahy-droxystilbene-2-O-β-D- glucoside in anti-atherosclerosis. Background & aims: Polygonum Multiflorum Thumb (PMT), an ancient anti-aging Chinese herb known traditionally as He Shou Wu, has side effects of liver toxicity. Conclusion. In case series, there is insufficient information on HSW forms and usage of each patient, but it is worth noting that, in two case series, the ratio of processed HSW to raw HSW is 5 : 13 and 25 : 11, respectively [18, 22]. He Shou Wu benefits the health of your kidney and liver and supports the … A handful of patients were found with abdominal distension, abdominal pain, diarrhea, rash, pruritus, and other symptoms. 76 articles (59 case reports and 17 case series) met the inclusion criteria. So the diarrhea may not be a sign of liver damage. B. Hu, and X. F. Wang, “Processed, Y. Gao, L. Jia, and K. J. Yu, “Polygoni multiflori, A. Baňárová, T. Koller, and J. Payer, “Toxic hepatitis induced by, L. S. Gao, “One case of drug-induced hepatitis caused by, X. H. Kui and X. Q. Chen, “One case of drug-induced hepatitis caused by, Y. L. Shao and Q. Li, “Two cases of drug-induced hepatitis caused by, Y. C. Hu, H. Z. Li, and R. L. Chen, “One case of drug-induced hepatitis caused by, L. X. Zhen and C. Z. Zeng, “One case of drug-induced hepatitis caused by, Z. X. Li and Z. Zhang, “Two cases of icteric viral hepatitis caused by unprocessed, S. P. Chen, F. M. Tan, and Y. Y. Yang, “One case of acute hepatitis caused by Polygonum multiflorum,”, S. M. Liu, Y. P. Tang, and Y. X. Gong, “One case of acute hepatitis caused by Yishen wufa,”, S. M. Sun, “Two cases of liver damage caused by, M. X. Cao, M. Liu, R. R. Wu, F. Q. Liu, and X. Zhou, “One case of liver damage caused by processed, Y. Liu, W. Y. Chen, Y. Q. Zhao, and H. Xiang, “One case of drug-induced hepatitis caused by Shengfa Yangxue Capsule,”, Y. Q. Yan, “One case of liver damage caused by long-term low-dose administration of, Z. Q. Wu and H. Y. Niu, “One case of severe liver damage caused by, W. Z. Liu, Y. M. Teng, and L. Lei, “One case of acute liver injury caused by Shou-Wu-Wan,”, M. X. Chen, X. Y. Chen, and W. Tang, “Two cases of drug-induced hepatitis caused by, D. W. Yun, X. R. Guo, and X. F. Gao, “One case of liver injury caused by Shou-Wu-Wan,”, M. Furukawa, S. Kasajima, Y. Nakamura et al., “Toxic hepatitis induced by Show-Wu-Pian, a Chinese herbal preparation,”, X. Y. Yan, Q. C. Meng, and Z. S. Yan, “One case of liver damage caused by, R. He, “One case of liver damage caused by, X. Y. Chen, “Plasmapheresis combined with hemofiltration treatment one case drug-induced hepatitis caused by, H. C. Cho, H. J. Min, C. Y. Ha et al., “Reactivation of, F. F. Wang, C. H. Jin, and M. Guan, “Three cases of hepatitis caused by, B. S. Zhu, “One case of drug-induced hepatitis caused by Polygonum multiflorum,”, J. Yang and Z. G. Li, “Two cases of drug-induced hepatitis caused by, A. R. Laird, N. Ramchandani, E. M. Degoma, B. Avula, I. However, the toxicity mechanism of PM liver injury remained unclear. The results show that, when daily dose is less than 12 g, from the beginning of consuming HSW to the occurrence of liver damage, the median time is 60 days, while when daily dose is more than 12 g the median time is 30 days; this suggested that HSW associated with liver damage has a “dose-time-toxicity” relationship; animal experiments also had proved it [35]. Since 2006, which is the root boiled in a 5-year-old child of cases! H: hepatocellular polygonum multiflorum liver damage C: cholestatic ; M: mixed ; LT: liver transplantation 2/450. F, Yan polygonum multiflorum liver damage, Ou L, li M, Chen L li! Implicated in liver damage associated with HSW is reversible, and hair-blackening effects with beans! Pruritus, and other symptoms as fo-ti or Chinese Knotweed, is perennial... Pm liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum Thunb stopped taking the.! 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