polygonum multiflorum side effects

This alkaloid demonstrates regulating effects on blood lipids and is being explored for its cardioprotective benefits. Selfhacked LLC does not provide medical advice, diagnosis, or treatment. It is known to induce laxative effects. Hot water extract of Fo-ti prevented bone loss (osteopenia) in a study on menopausal mice [25]. Avoid the use if debilitated with Phlegm, Stomach, and Spleen Disorders. Side Effects and Benefits of Polygonum multiflorum [Chinese knotweed] Polygonum multiflorum [Chinese knotweed, Flowery knotweed; as fo-ti, fo-ti-teng, ho shou wu, or he shou wu; 何首烏] How does polygonum multiflorum (Chinese knotweed) benefit people at aging-process? Polygonum multiflorum can interact with certain medications and may be inappropriate for individuals with certain health conditions. Polygonum multiflorum (Fo-ti) is a popular herb in traditional Chinese medicine. This processed Fo-ti is said to prevent heart disease by not allowing plaque to form in the blood vessels. TSG prevented atherosclerosis by reducing lipid levels in the blood and suppressing inflammation (via the MMP-2 and MMP-9 genes) in another study on rats [15]. Anecdotally, general side effects include diarrhea, nausea, abdominal pain, and vomiting. It contains the substance emodin, which is a laxative and also is thought to be a liver protective agent. SelfDecode provides recommendations that are personalized based on YOUR genes to help you stay healthy and avoid infections from viruses like COVID-19! Polygonum multiflorum (witch hazel) is often recommended for topical use but in traditional Chinese medicine it is also used orally. Ever try supplements that don’t seem to work? Als eine der wichtigsten Pflanzen in der traditionellen chinesischen Kräuterkunde hat Fo-Ti unsere vollste Aufmerksamkeit verdient – und genau die wollen wir dem vielblütigen Knöterich, dem sogenannten Polygonum multiflorum, heute schenken. Polygonum multiflorum Thunb. Further research is required to understand the potential heart-friendly effects of Fo-ti. No valid clinical evidence supports the use of Fo-ti for any of the conditions in this section. According to the available evidence, it can not be suggested as a complementary approach for cancer treatment or prevention. Some secondary effects of this may include increased sexual desire, strengthened sexual performance, increased energy and restored hair growth. The kidneys are often referred to as “the root of vitality” in TCM, since they are involved in essential life processes, including supporting our metabolism, reproduction, blood clean… Additionally, processing of Fo-ti resulted in the formation of five new chemicals that were not identified in the crude herb [2]. According to the Natural Medicines Comprehensive Database, oral usage is considered “possibly unsafe” for adults and children due to several reports of liver damage. Read on to learn the potential uses and side effects of Fo-ti. Planta Med 2010;76(9):889-92. TSG and emodin in Fo-ti decreased inflammation and helped with colitis in mouse models by increasing PPAR-gamma and decreasing NF-kB [2, 3, 17]. Information is shared for educational purposes only. Polygonum multiflorum contains more than one hundred different phytonutrient (plant chemical) compounds. Hepatotoxicity and hepatoprotection of Polygonum multiflorum Thund. It has also been shown to protect liver cells from damage by toxins including dry cleaning fluid. We do not aim to diagnose, treat, cure or prevent any illness or disease. Polygonum multiflorum extract supplementation may help the body to synthesize more of an antioxidant called superoxide dismutase (SOD). So who is this guy and what does his black hair have to do with anything?Li Ao was a Taoist during the Tang Dynasty (618-907 A.D.). He shou wu is said to act as an adaptogen, building the body’s defenses against stress, and also to support the balance between yin and yang energies. Its popular usage stems mainly from historical records of its use for low libido, suppressed immunity, cardiovascular inefficiency and as a laxative. This site uses Akismet to reduce spam. In a study on mice, P. multiflorum extracts promoted hair growth by stimulating hair follicles [38]. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. The significance of the plant is from the reddish roots which are usually boiled with black beans to form a preparation called the red Fo-ti. Fo-ti may have significant interactions with other drugs that are metabolized by the liver, anti-diabetes drugs, laxatives, and more. The present study investigated the antiosteoporotic effect of PM on bone mass in ovariectomized (OVX) mice and its possible mechanism of action. Research on Polygonum multiflorum shows that it contains alkaloid compounds. An herbal mixture containing Fo-ti significantly reduced LDL cholesterol and triglycerides in a study of 42 participants. Fo-ti had anti-bacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) in one cell-based study [21]. Han MN1, Lu JM1, Zhang GY1, Yu J1, Zhao RH1. Your email address will not be published. Objective. P. multiflorum and its extracts should be considered hepatotoxic; however, the plant is widely used in traditional Chinese medicine and Ayurvedic medicine for its rejuvenating and toning properties, to increase liver and kidney function, for treatment of cognitive di… Fo-ti prevented the HIV virus from entering lymphocytes in a cell-based study [22]. Before taking fo-ti, talk to your healthcare provider if you take any medications that are changed by the liver. Animal research shows that P. multiflorum reduces fat deposits inside the liver. The present study investigated the antiosteoporotic effect of PM on bone mass in ovariectomized (OVX) mice and its possible mechanism of action. To summarize the characteristics and analysis of relevant factors and to give references for prevention and further study of liver damage associated with Polygonum multiflorum Thunb. Save my name, email, and website in this browser for the next time I comment. J Ethnopharmacol. Polygonum multiflorum is the botanic name for He Shou Wu or Fo Ti – an ancient herbal remedy used in Chinese medicine for anti-aging benefits. The leaves, root tuber, and rhizomes have been used as a tonic in the anti-aging formula while the stem has been used to alleviate insomnia, help with diabetes, stimulate the immune system, and more [3, 4]. Therefore, … It is widely cultivated throughout China and other countries such as Japan, where it grows in valley shrubs, hillside forests, gutter rock crevices and other locations at altitudes of 200 – 3,000 m [2]. It is probably best known for it’s ability to turn grey hair dark again. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at [email protected]. Fo Ti can have severe side effects that sometimes have been attributed wrongly to he shou wu due to this confusion. The plant grows to be 2-4 m tall consisting of a woody tuber, leaves are long and arrowhead-shaped, white or greenish-white flowers, and an achene fruit [2]. Epub 2011 Nov 20. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better. Some of these include stilbene glycosides, flavonoids and quinones which are known to exhibit beneficial physiological effects. The effect of PM extract on bone weight and length was evaluated. For centuries, Polygonum multiflorum has been used an herbal medicine by the Chinese. as two sides of the same biological coin. Torachrysone-8-O-β-D-glucoside, a compound found in P. multiflorum, can significantly increase the number of dermal papilla cells which play a role in hair growth and hair fiber length [39]. P. multiflorum may also be toxic to the kidneys (nephrotoxicity) and the lungs (pulmonary toxicity), particularly after long-term use. Polygonum multiflorum (PM), a traditional Chinese medicine, is used to treat various diseases including nonalcoholic fatty liver disease and hyperlipidemia. The list of side effects below is not a definite one, and you should consult your doctor about other potential side effects, based on your health condition and possible drug or supplement interactions. Fo-ti has traditionally been used to treat patients suffering from baldness and hair loss throughout East Asia. This plant is also used to darken hair that has greyed prematurely. Epub 2015 Nov 10. Evidence exists of hepatic injury in humans. However, the influence of PM on osteoporosis in animals is unclear. All of our content is written by scientists and people with a strong science background. In test tubes, stilbene glucoside from Fo-ti inhibited tissue aging due to high blood sugar [29]. Polygonum multiflorum is a widely used herbal medicine in China and Japan, and there were 61 Chinese patent drugs collected in Chinese Pharmacopoeia 2015 edition that contained PM or its preparations. In test tubes, scientists observed the potential of Fo-ti to stimulate the production and activity of T cells, B cells, and natural killer (NK) cells [20, 2]. Check with your doctor to determine if this supplement is appropriate for you. More than 100 chemical compounds have been isolated from Fo-ti, and the most biologically relevant components have been determined to be from the families of stilbenes, quinones, flavonoids, and phospholipids. … TSG protected diabetic mice against kidney damage from high blood sugar through SIRT1 and TGF-beta pathways [27, 28]. Fo-ti components showed inhibitory effects against various types of cancer cells in test tubes, but this doesn’t reveal much about their potential anticancer effects in living beings [2, 37, 2]. In North America, it is called fo-ti. One alkaloid (2, 3, 5, 4′-tetrahydroxystilbene-2-O-beta-D-glucopyranoside (TSG)) in P. multiflorum is believed to induce restoring effects on brain cells, neurons and endocrine glands. data of protective effects of commercially available Polygonum multiflorum extract (PME) in vivo on aging and life span are limited. Fo-ti is also used in TCM for other conditions, including:1 1. Atherosclerosis 2. Polygonum multiflorum extract supplements are marketed for purposes including combating aging, restoring sexual vigor, enhancing cellular health, stimulating the adrenal glands, detoxifying the blood and improving endocrine functioning. Required fields are marked *. Hyperlipidemia, hypercholesterolemia and hypertriglyceridemia are conditions of blood lipid imbalance. Most notably — although rare — t’s been linked to cases of liver damage. Ruan LY(1), Li MH(1), Xing YX(1), Hong W(1), Chen C(1), Chen JF(1), Xu H(1), Zhao WL(1), Wang JS(2). However, there is very limited research into the safety of this supplement. Wang T, Wang JY, Zhou ZX, Jiang ZZ, Li YY, Zhang L, Zhang LY. SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. Anti-HIV activities of the compounds isolated from Polygonum cuspidatum and Polygonum multiflorum. Overdose may cause Nausea, Vomiting, Diarrhea. Some research suggests that long-term use of He Shou Wu can cause dangerous side effects. Anecdotally, Fo-ti exhibits a wide spectrum of pharmacological effects, including anti-aging, immunologic, neuroprotective, anticancer and anti-inflammatory effects. based on YOUR genes to help you stay healthy and avoid infections from viruses like COVID-19! Side Effects, Risk Factors of, and Cautions for Polygonatum Avoid in case of Pregnancy and Breastfeeding. It has been used for thousands of years to promote long life, nourish blood, strengthen bones, tendons and muscles as well as many other purposes. Fo-Ti is widely used to strengthen the lower back and knees. Effect of Polygonum multiflorum on thymus and splenic weights in ovariectomized mice. However, you shouldn’t interpret them as supportive of any health benefit. The sugars (rhamnose, arabinose, xylose, and glucose) and anthraquinone glycosides from Fo-ti have immune-stimulating properties [2]. The best-known toxicity of P. multiflorum is liver or hepatotoxicity. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. Can Vitamin D Reduce the Likelihood of Cancer. The most common side effect is weird dreams and being too groggy the next day. After receiving several reports of liver disorders, including jaundice and hepatitis, the UK Medicines and Healthcare products Regulatory Agency (MHRA) issued a warning about the risks of using Polygonum multiflorum, advising members of the public who experience symptoms of liver disorders while taking products that contain Polygonum multiflorum to see their doctor and to stop taking the product …

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